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BestCrosswords.com - "I Know, I Know" by Frank Virzi on 10/1/2017 [moderate]
Across 1- Submissions to eds.; 4- Suds source; 7- Blood-typing system; 10- '90s Pacers center Smits; 13- Prefix with cycle; 14- Prior to A.D.; 15- "___ is Painless": "M*A*S*H" theme song; 17- One who flits from group to group; 20- Rubs the wrong way; 21- Orderly grouping; 22- Author Robert ___ Butler; 23- On ___: sandwich specification; 25- Indigo dye source; 26- "Who are ____ argue?"; 27- Candy with a hole in the middle; 29- Send; 30- Prefix with conference; 31- Abilene-to-Waco dir.; 33- French soul; 34- Last pope of the 1700s; 37- Needle user; 39- Dadaist Jean; 40- Superscript number: Abbr.; 42- Goalie's feat; 43- Violinist's supply; 45- Song with the line, "Mars ain't the kind of place to raise your kids"; 50- Boomers; 51- First of 13 popes; 52- Ocho minus uno; 53- Suffix with myth; 54- Exeunt ___: all go out; 56- Opposite of bianca; 57- "Broken Arrow" star; 60- Wave through, as at a guard station; 61- Windy City rail inits.; 62- Denver clock setting: Abbr.; 63- Failing grades; 64- Fannie or Ginnie follower; 65- Hook shape; 66- D.D.E.'s command;   Down 1- Cardinal Hall of Famer Stan; 2- "Edda" author ___ Sturluson; 3- Fed up with; 4- Alley org.; 5- The Bruins of the Pac Ten; 6- "Fear not!"; 7- "Steps in Time" autobiographer; 8- Synthetic rubber used in inner tubes; 9- French goose; 10- Chuck Connors role; 11- Period of relaxation; 12- Obama at the 2004 DNC; 16- "Mystery, Alaska" star; 18- Specks in the sea; 19- Large vase: Fr.; 24- Square, in old slang, as indicated by forming a square with one's hands; 28- TV actress ___ Elias; 29- Splits, old-style; 32- Neb. neighbor; 34- Proton or electron; 35- Hit Japanese TV import; 36- Presumptuous nouveaux riches; 38- It contains rods and cones; 41- Basis of an argument; 42- Word that can follow the starts of 17-, 27-, 45-, and 57-Across; 44- Long Island town; 46- Mrs. Chaplin; 47- Lover's message; 48- Not moving; 49- Close by; 51- "____ luck!"; 55- Retired fleet; 58- Friend of Frodo; 59- ___ Cruces;