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BestCrosswords.com - "One on One" by Frank Virzi on 10/25/2012 [moderate]
Across 1- Generation X, e.g.; 9- Actress Henner; 15- Like a fillet; 16- Pioneering geneticist; 17- In need of company; 18- Drew Barrymore's great-uncle; 19- Where Adam spared a rib?; 20- Prefix meaning "self"; 22- Reproachful clucks; 23- Part of a play; 26- Smeltery waste; 29- Bullish order on Wall Street; 32- O?; 34- Opposite of ESE; 35- Painter's deg.; 38- Having a pressing need?; 41- Attacked; 43- Series set at 328 Chauncey Street in Brooklyn; 45- Gay, in a bookstore?; 46- Elevated standing; 47- Basic version: Abbr.; 48- American ___; 50- Having four sharps; 51- Last word of "America, the Beautiful"; 52- State in NE India; 54- Important econ. indicator; 56- "The Good Earth" mother; 59- Blood test letters; 61- Gas brand in Canada; 65- Introverts; 68- High-ranking army officers; 71- Approach; 72- Como and Crosby; 73- Not seeing eye to eye; 74- If you look at it the right way;   Down 1- Experienced; 2- Well-behaved; 3- Feminine suffix; 4- Susan's "Thelma & Louise" co-star; 5- "Dr. Jekyll and Mr. Hyde" monogram; 6- Antipoverty agcy.; 7- DDE's alma mater; 8- Nom de plume: Abbr.; 9- CCXXX x V; 10- "Prince ___" ("Aladdin" song); 11- Underground network; 12- Lodges; 13- Vichyssoise ingredient; 14- WWW addresses; 21- Old credit-reporting company that became Experian; 24- Picks; 25- Travels mole-style; 27- Like many investigations; 28- Was weak in the knees; 29- Ashtray accumulation; 30- Take away a beret; 31- Traffic sign; 33- "Holy cow!"; 35- Has-____ (former stars); 36- Madcap comedy; 37- Befuddled; 39- Baseball-stat trio; 40- Stain; 42- Austin-to-Dallas dir.; 44- When George W. Bush was sworn in; 49- ___-jongg; 52- On ____-to-know basis; 53- Start of the 18th century; 55- Ziti alternative; 56- One of Chekhov's Three Sisters; 57- Spoils; 58- Cornerstone word; 60- Forsaken; 62- Observed; 63- Some cameras, for short; 64- Bone: Prefix; 66- "Far out!"; 67- Yearbook sect.; 69- Hawaii's Mauna ___; 70- Decade in which the 21st century began;